Identification of a New Commonly Deleted Region within a 2-cM Interval of Chromosome 11p11 in Breast Cancers

  • Nakata T.
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School
  • Yoshimoto M.
    Department of Surgery
  • Kasumi F.
    Department of Surgery
  • Akiyama F.
    Department of Pathology, Cancer Institute
  • Sakamoto G.
    Department of Pathology, Cancer Institute
  • Nakamura Y.
    Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo
  • Emi M.
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

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説明

Allelic loss has been observed on the short arm of chromosome 11 in a variety of human cancers. We have examined 184 breast cancers for allelic loss anywhere in chromosome 11p, using 15 well-spaced microsatellite markers. Allelic loss was observed in 86 cases (47%) and a new commonly deleted region 2-cM in length was identified at 11p11 between loci D11S986 and D11S1313,in addition to a 12-cM region of a common deletion at 11p15.5. A significant association was found between allelic loss on 11p15.5 and LOH on 11p11 and the loss of progesterone receptors. [○!C] 1998 Elsevier Science Ltd. All rights reserved.

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詳細情報 詳細情報について

  • CRID
    1571135651853716224
  • NII論文ID
    110001071219
  • NII書誌ID
    AN1047681X
  • ISSN
    13409662
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

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