Studies on Bi-heterocyclic Compounds. I. 6-Substituted Dihydro-1,4-thiazinones(Organic,Chemical)

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説明

Reactions of 5-inethyl-2H-1,4-thiazin-3(4H)-one (4) with various N-acylpyridinium salts (7a-g) led to (N-acyldihydropyridyl)thiazinones (5a-g), oxidation of which yielded a new class of pyridylthiazinones (6a-g). These reactions were applied to the synthesis of other azaarylthiazinones. Some of these azaarylthiazinones, particularly 6-(4-pyridyl)thiazinones (6a, 14a and 14b) showed positive inotropie activity with little chronotropic effect on guinea pig left atria.

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詳細情報 詳細情報について

  • CRID
    1571135652302067968
  • NII論文ID
    110006281208
  • NII書誌ID
    AA00602100
  • ISSN
    00092363
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

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