The Molecular Structure of Procaterol Hydrochloride Hemihydrate [5-(1-Hydroxy-2-isopropylaminobutyl)-8-hydroxy-2-quinolone Hydrochloride Hemihydrate, OPC-2009]
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The molecular structure of procaterol hydrochloride hemihydrate (C_<16>H_<22>N_2O_3・HCl・1/2H_2O) was determined by X-ray diffraction analysis. The crystal is orthorhombic with the space group P22_12_1 and Z=4. The cell dimensions are a=7.247 (2), b=12.491 (8), and c=18.822 (13) A. The structure was solved by a direct method using the MULTAN program and refined by a block-diagonal least-squares method to give a final R-value of 0.069. The N (2')^+ cation of the side chain forms two hydrogen bonds with Cl^- anion and a water molecule but not with O (3') atom, although O (3')-C (11)-C (12)-N (2') is gauche (53°) with a close intramolecular N (2')-O (3') distance of 2.679 (7) A. It was confirmed by proton magnetic resonance spectroscopic measurements that the molecular conformation found in the crystal is retained in solution as a preferred conformation.
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 30 (1), 44-50, 1982-01-25
公益社団法人日本薬学会
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- CRID
- 1571135652348581504
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- NII論文ID
- 110003634058
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- en
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