New 1,4-Dihydropyridine Derivatives with Potent and Long-Lasting Hypotensive Effect

被引用文献2件
  • 目黒 寛司
    Central Research Division, Takeda Chemical Industries, Ltd.
  • 相沢 正博
    Central Research Division, Takeda Chemical Industries, Ltd.
  • 左右田 隆
    Central Research Division, Takeda Chemical Industries, Ltd.
  • 川松 豊
    Central Research Division, Takeda Chemical Industries, Ltd.
  • 永岡 明伸
    Central Research Division, Takeda Chemical Industries, Ltd.

書誌事項

公開日
1985
公開者
公益社団法人日本薬学会

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説明

In a search for new 1,4-dihydropyridine derivatives with a long-lasting effect on the cardiovascular system, a series of piperazinylalkyl esters (I) bearing a lipophilic substituent on the 4-nitrogen of the piperazine ring was synthesized and tested for hypotensive effect in spontaneously hypertensive rats (SHR). Compounds I, especially those having a diphenylmethyl moiety on the piperazine ring, showed extremely potent and long-lasting hypotensive properties. Analogues related to I were also prepared, and the structure-activity relationships are discussed.

収録刊行物

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 33 3787-3797, 1985

    公益社団法人日本薬学会

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