Studies on Secretin. I. Synthesis of Completely Protected Secretin

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In order to establish a new process for large-scale production of highly purified secretin, a synthesis based on a new strategy was investigated. A maximal protection method applying the HF deprotecting procedure in the final stage was employed. Six small protected fragments (2-6,7-10,11-13,14-17,18-22,23-27) were each prepared by stepwise chain elongation. Thereafter, three protected fragments (1-10,11-17,18-27) were synthesized from them, and assembled to prepare the protected secretin. The optical purity of the product after each fragment condensation was checked by high performance liquid chromatography. Completely protected secretin having a high degree of chemical and optical homogeneity was obtained.

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