スナネズミ悪性黒色腫の組織培養に関する研究

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  • 森友 忠昭
    日本大学農獣医学部獣医学科魚病学研究室
  • 斉藤 寛史
    日本大学農獣医学部獣医学科臨床病理学研究室
  • 渡辺 翼
    日本大学農獣医学部獣医学科魚病学研究室
  • 望月 公子
    日本大学農獣医学部獣医学科実験動物学研究室

書誌事項

タイトル別名
  • Tissue Culture Study on Mongolian Gerbil's (<I>Meriones unguiculatus</I>) Malignant Melanoma

抄録

We tried to culture melanoma cells from a Mongolian gerbil's (Meriones unguiculatus) malignant tumor. In primary culture, most of cells have abundant melanin granules in their cytoplasm. Melanin granules decreased through 5 to 15 serial passages and disappeared after 15 th passage. The morphology of the cells varied from spindle to large polydendritic cells. Although typical melanin granules were not seen when the cells were stained by Masson-Fontana method, the cells were positive for DOPA reaction. Electron microscopically, most of the cells have well-developed Golgi apparatus and rough-surfaced endoplasmic reticulum with dilated cistern, and premelanosome-like granules were frequently observed in their cytoplasm.

収録刊行物

  • Experimental Animals

    Experimental Animals 40 (3), 385-388, 1991

    公益社団法人 日本実験動物学会

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