Comparative Studies of Aa1 Allotypic Specificity in IgG and IgM of Rabbits:II. Phenotypic Expression of Allotypic Specificities in Rabbits Exposed in Neonatal Life to Antibodies Directed against Aa1 Allotypic Determinants Specific for IgG

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  • SETO Akira
    The Department of Microbiology, Faculty of Medicine, Kyoto University

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Neonatal rabbits were treated with antibodies directed against Aa1 allotypic determinants specific for IgG and its effects on development of allotypically determined immunoglobulins were analysed in sera of the treated animals. The treatment of Aa1 Aa3 heterozygous rabbits resulted in a delayed appearance in serum of all or some Aa1+ immunoglobulins: In some animals neither Aa1+ IgG nor Aa1+ IgM were detected for 9 weeks after birth and in others no Aa1+ IgG only Aa1 IgM was found up to 5 weeks after birth. In Aa1 Aa1 homozygous rabbits, no similar effect was observed. Another effect of the treatment was manifested as supernormal levels of serum IgG and IgM with a maximum at 9 weeks. This effect was more remarkable in homozygotes than in heterozygotes in which phenotypic expression of some Aa1 allotypic patterns was suppressed. In other heterozygotes in which phenotypic expression of all Aa1 allotypic patterns was suppressed, IgG levels were lower than controls, suggesting that the suppressed phenotypic expression was not compensated. Quantitative analyses of IgG molecules carrying Aa1 allotypic specificity have revealed that approx. only 40% of IgG molecules carried the Aa1 allotypic determinants specific for IgG in an IgG preparation from an Aa1 Aa1 homozygote in which more than 60% of the molecules possessed Aa1 allotypic specificity.

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