A Novel Low-Density Lipoprotein Receptor-Related Protein with Type II Membrane Protein-Like Structure Is Abundant in Heart.
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- Tomita Yasuhiro
- Tohoku University Gene Research Center
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- Kim Dong-Ho
- Tohoku University Gene Research Center
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- Magoori Kenta
- Tohoku University Gene Research Center
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- Fujino Takahiro
- Tohoku University Gene Research Center
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- Yamamoto Tokuo T.
- Tohoku University Gene Research Center
説明
We report herein the identification of a novel member of the low-density lipoprotein receptor (LDLR) family termed LDLR-related protein 4 (LRP 4). Murine LRP 4 cDNA encodes a 1113-amino-acid type II membrane-like protein with eight ligand-binding repeats in two clusters. Southern blot analysis of genomic DNA from several different organisms suggests the presence of LRP 4 homologues in chicken lacking the gene encoding apolipoprotein E, which is recognized by the ligand-binding repeats of LDLR. LRP 4 transcripts were detected almost exclusively in heart in mouse and humans. Despite the presence of the ligand-binding repeats, COS cells transfected with LRP 4 did not show surface-binding of β-migrating very-low-density lipoprotein, suggesting that LRP 4 plays a role in a pathway other than lipoprotein metabolism.
収録刊行物
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- The Journal of Biochemistry
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The Journal of Biochemistry 124 (4), 784-789, 1998
The Japanese Biochemical Society
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詳細情報 詳細情報について
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- CRID
- 1571135653116896896
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- NII論文ID
- 130003417811
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- ISSN
- 0021924X
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles