Spontaneous and Enzymatic Activations of Carcinogenic N-Butyl-N',N'-dimethyl-N-nitrosourea(Biological)
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- KOHDA KOHFUKU
- Faculty of Pharmaceutical Sciences, Nagoya City University
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- HAKURA ATSUSHI
- Faculty of Pharmaceutical Sciences, Nagoya City University
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- NlNOMIYA SHIN-ICHI
- Faculty of Pharmaceutical Sciences, Nagoya City University
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- KAWAZOE YUTAKA
- Faculty of Pharmaceutical Sciences, Nagoya City University
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Description
N-Butyl-N',N'-dimethyl-N-nitrosourea (DM-BNU), the spontaneous (hydrolytic) activation rate of which is 4×10^<-4> times that of N-butyl-N-nitrosourea (BNU), is metabolized to N-butyl-N'-methyl-N-nitrosourea (MM-BNU) in the presence of S9 mix. It is, therefore, suggested that the carcinogenicity of DM-BNU, which is as potent as that of BNU, may be attributed partly to the demethylated MM-BNU, which is more readily activated to a carcinogenic reactant. This hypothesis is supported by the mutagenicilies of these carcinogens in E. coli in the presence and absence of S9 mix.
Journal
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 34 (12), 5056-5062, 1986-12-25
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1571417127278693632
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- NII Article ID
- 110006280838
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- NII Book ID
- AA00602100
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- ISSN
- 00092363
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- Text Lang
- en
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- Data Source
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- CiNii Articles