INTESTINAL ABSORPTION AND METABOLISM OF NORCHOLIC ACID IN RATS

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Intestinal absorption and hepatic and intestinal bacterial biotransformations of norcholic acid, the C_<23> homologue of cholic acid, were studied in the rats. Norcholic acid, like cholic acid, was effeciently absorbed from the intestine and quickly secreted into the bile. Unlike the C_<24> bile acid, however, which is secreted by rat liver as its taurine conjugate, the C_<23> bile acid appeared in the bile predominantly as the unconjugated form. conjugated form. Bacterial modification of norcholic acid was similar to but less extensive than that of cholic acid. A considerable part of norcholic acid was left unchanged during its passage through the intestinal tract. A major bacterial metabolite of norcholic acid was the 7-dehydrogenation product, 7-detonordeoxycholic acid, rather than the 7-dehydroxylation product, nordeoxycholic acid, though the reverse is true for cholic acid.

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