An Alternate Synthesis of Leupeptins and Their Analogs
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説明
It was found that lithium aluminum hydride reduction of N^a, N^G-disubstituted arginine lactam (3a-c) at a low temperature gave a corresponding argininal derivative (4a-c). Analogous reduction of acetyl-L-leucyl-L-leucyl-N-benzyloxycarbonyl-L-arginine lactam (8b) or its dipeptide analog (13) yielded leupeptin Ac-LL(1a) or acetylleucyl-argininal (11) respectively. Antiplasmin activities of these synthetic leupeptins were also reported.
収録刊行物
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 21 (1), 163-170, 1973-01-25
公益社団法人日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1571417127437257856
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- NII論文ID
- 110003621449
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles