<Review>Design and Development of New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids

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  • <総説>プラズマ照射を利用する新規なドラッグデリバリーシステムの設計と開発

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A new controlled release drug delivery system (DDS) was established by oxygen plasma irradiation (radio-frequency discharge at 13.56 MHz) on the outermost layer of a doubly compressed tablet consisting of drug as core material and various polymers as wall material. Polymers were selected on the basis of effects of plasma irradiation dependent on polymer structure such as polyoxymethylene (POM), typically a plasma-degradable polymer, polystyrene (PST), a plasma-crosslinkable polymer, polycarbonate (PC), a bifunctional polymer having plasma-degradable and crosslinkable positions in the molecular structure, polybenzylmethacrylate (PBzMA) having a plasma-degradable main chain and plasma-crosslinkable functional group in the side chain and copolymer of methylmethacrylate (MMA) and benzylmethacrylate (BzMA). To expand applications of this DDS in various dosage forms, theophylline release was studied from plasma-irradiated polymer-coated granules. The present approach is superior to other methods for producing DDS, such as avoidance of direct plasma-exposure to a drug, being a totally dry process to eliminate any work up required in conventional wet processes, and a limited surface so that bulk properties of polymeric pharmaceutical aids are not affected.

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