Susceptibility of Four Species of Small Rodents to Encephalomyocarditis (EMC) Virus Infection
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- MATSUZAKI Hitoshi
- <I>Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo</I>
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- DOI Kunio
- <I>Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo</I>
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- DOI Chiyo
- <I>Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo</I>
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- ONODERA Takashi
- <I>Laboratory of Immune Cytology, National Institute of Animal Health</I>
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- MITSUOKA Tomotari
- <I>Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo</I>
Bibliographic Information
- Other Title
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- 4種の小型げっ歯類の脳心筋炎ウイルスに対する感受性
Abstract
The D variant of encephalomyocarditis virus (101-105 PFU/head) was intraperitoneally inoculated into 4 species of small rodents, rats, mice, Syrian hamsters, and Mongolian gerbils, and the susceptibillity of these animals to EMC virus was examined virologically and histopathologically 3 days after infection. Viral replication was detected in the brain (mice), in the heart (mice and gerbils), and in the pancreas (mice, hamsters, and gerbils) . No viral replication was detected in rats. Histopathological changes were seen in the brain (mice and hamsters), in the heart (mice and gerbils), and in the pancreas (mice, hamsters, and gerbils) . No histopathological changes were seen in rats. The present results suggest that it may be quite passible to produce EMC virus-induced diabetes mellitus not only in mice but also in hamsters and gerbils.
Journal
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- Experimental Animals
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Experimental Animals 38 (4), 357-361, 1989
Japanese Association for Laboratory Animal Science
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Details 詳細情報について
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- CRID
- 1571417127949607296
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- NII Article ID
- 130006940571
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- Data Source
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- CiNii Articles