Hypercholesterolemia in Anorexia Nervosa According to Superior Mesenteric Artery Syndrome

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  • 神経性食思不振症における高コレステロール血症の発症に関する検討

Abstract

We measured lipid and apolipoprotein concentration in the serum of 11 patients with anorexia nervosa, comparing values with those for age- and sex-matched controls, and found significantly increased serum total cholesterol, LDL-cholesterol, apolipoprotein A-1 and apolipoprotein B in patients. Serum total cholesterol and LDL-cholesterol were correlated with the serum total and direct fractions of bilirubin, but not correlated with the amount of body weight loss, triiodothyronine and thyroxine.<br>Among 11 patients with anorexia nervosa, serum total cholesterol, LDL-cholesterol and apolipoprotein B concentrations were higher in those with (n=6) than in those without superior mesenteric artery syndrome or a similar syndrome (n=5).<br>These results indicate that cholestasis is induced by superior mesenteric artery syndrome in the pathogenesis of hypercholesterolemia in anorexia nervosa.

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