Isolation and Identification of Hypotensive Principles in Red-Mold Rice(Biological)

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During an initial search for pharmacologically active principles in red-mold rice, two hypotensive compounds were isolated and identified. The active principles, A-3 and B-1, were fractionated and purified from the EtOH extract of red-mold rice prepared with Monascus pilosus through extraction with H_2O, Amberlite CG-120 column chromatographies and high-performance liquid chromatography on an ODS column. A-3 was identified as acetylcholine chloride by comparison with an authentic sample, and B-1, colorless needles of mp 203-205℃, was proved to be identical with authentic γ-aminobutyric acid. Intravenously administered A-3(0.5μg/kg) and B-1(250μgAg) produced potent depression of the carotid arterial blood pressure in spontaneously hypotensive rats, as did the corresponding authentic samples.

Journal

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 35 2484-2489, 1987

    The Pharmaceutical Society of Japan

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