Solvate Formation of Griseofulvin with Alkyl Halide and Alkyl Dihalides

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説明

Six solvates of griseofulvin with alkyl halide and alkyl dihalides were isolated, and their crystallographic as well as physico-chemical propetries were investigated by infrared spectroscopy, powder X-ray diffiractometry, x-ray crystallographic analysis, thermogravimetry (TG) and differential scanning calorimetry (DSC). From the weight loss in TG curves, the combining ratios between the drug and solvent were determined to be 1 : 1 except for that of griseofulvin 1-bromo-2-chloroethane solvate (drug : solvent=1 : 0.8). The cell dimensions of griseofulvin bromoethane solvate and griseofulvin dibromomethane solvate were almost equal, and the solvates fromed a new type of mixed crystal (substitutional solid solution).From X-ray crystallographic analysis, it was elucidated that the molecular arrangement in the dichloroethane solvate crystal was the same as that in the chloroform solvate determined by Shefter et al.

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詳細情報 詳細情報について

  • CRID
    1571698602413810688
  • NII論文ID
    110003626755
  • NII書誌ID
    AA00602100
  • ISSN
    00092363
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

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