ラットにおけるpepsinogenの新しい多型遺伝子座 (<I>Pg-2</I>)

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書誌事項

タイトル別名
  • A New Polymorphic Pepsinogen Locus (<I>Pg-2</I>) in the Rat (<I>Rattus norvegicus</I>)

抄録

Only two types of pepsinogens, which are products of the Pg-1 locus, are present in rat urine. In gastric mucosa, however, additional pepsinogen isozymes are expressed. We have found a polymorphism for rat gastric mucosa pepsinogen using agarose gel electrophoresis. Some inbred rat strains expressed a pepsinogen band, while others did not. The trait was found to be controlled by a single autosomal locus. We tentatively designated the locus as Pg-2 with two alleles, Pg-2a for the one controlling presence of the band and Pg-2o for the one controlling absence. Linkage analysis using BN and TM strains revealed that Pg-2 was closely linked to Pg-1 (3.7±1.8cM), and that it did not belong to LG I (Hbb and p), LG II (Aeon-1 and Mup-1), LG IV (Hao-1 and Svp-1), LG V (Es-1 and Es-3), LG VI (Gc and h), LG IX (RT1), LG X (Fh and Pep-3), nor a LG containing Ahd-2 (as yet undetermined) .

収録刊行物

  • Experimental Animals

    Experimental Animals 36 (3), 267-272, 1987

    公益社団法人 日本実験動物学会

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