A New Low Density Lipoprotein Receptor Related Protein, LRP5, Is Expressed in Hepatocytes and Adrenal Cortex, and Recognizes Apolipoprotein E1.
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- Kim Dong-Ho
- Tohoku University Gene Research Center
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- Inagaki Yousuke
- Tohoku University Gene Research Center
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- Suzuki Takashi
- Department of Pathology, School of Medicine, Tohoku University
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- Ioka Ryoichi X.
- Tohoku University Gene Research Center
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- Yoshioka Shiroh Z.
- Tohoku University Gene Research Center
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- Magoori Kenta
- Tohoku University Gene Research Center
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- Kang Man-Jong
- Tohoku University Gene Research Center
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- Cho Yuko
- Tohoku University Gene Research Center
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- Nakano Akira Z.
- Tohoku University Gene Research Center
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- Liu Qiong
- Tohoku University Gene Research Center
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- Fujino Takahiro
- Tohoku University Gene Research Center
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- Suzuki Hiroyuki
- Tohoku University Gene Research Center
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- Sasano Hironobu
- Department of Pathology, School of Medicine, Tohoku University
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- Yamamoto Tokuo T.
- Tohoku University Gene Research Center
説明
The isolation and characterization of rabbit and human cDNAs revealed a new low density lipoprotein receptor (LDLR)-related protein (LRP) designated as LRP5. Human LRP5 cDNA encodes a 1, 616-amino acid type I membrane-like protein with three ligand binding repeats in its extracellular region. LDLR-deficient cells transduced by recombinant adenovirus containing human LRP5 exhibited increased binding of apolipoprotein E (apoE)-enriched β-migrating very low density lipoprotein. Northern blotting and in situ hybridization revealed a high level of LRP5 expression in hepatocytes and the adrenal gland cortex. In LDLR-deficient Watanabe heritable hyperlipidemic rabbits, LRP5 mRNA was increased in the liver and accumulated in cholesterol-laden foam cells of atherosclerotic lesions.
収録刊行物
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- The Journal of Biochemistry
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The Journal of Biochemistry 124 (6), 1072-1076, 1998
The Japanese Biochemical Society
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詳細情報 詳細情報について
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- CRID
- 1571698603081206272
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- NII論文ID
- 130003533556
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- ISSN
- 0021924X
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles