Clinical Study of Tranexamic Acid Cream on Melasama A Multi-center Double Blind Trial

J-STAGE

Bibliographic Information

Other Title
  • 色素沈着症に対するトラネキサム酸クリーム外用の効果

Description

The first study was designed to compare the effects on melasma between 5% tranexamic acid ceream and 0.5% tranexamic acid cream by means of double-blind inter-group comparison. The percentage of cases where treatment was rated as slightly useful or better was over 70% in both the 5% tranexamic acid cream group and the 0.5% tranexamic acid cream group. The second study was designed to evaluate the effects on melasma of 5% tranexamic acid cream in comparison to drug-free ream base by means of double blind inter-group comparison. The percentage of cases where treatment was rated as slightly useful of better did not differ markedly between the 5% tranexamic acid cream group(54%) and the drug-free cream group(48%). In stratified analylis(analysis by the severity of melasma), however, the percentage of cases with sever melasma showing alleviation in respose to treatment was 85.7% in the 5% tranexami acid cream group(n=7) and 30.0% in the drug-free cream base group(n=10), and this difference was statistically significant(U test).

Journal

  • Skin research

    Skin research 6 (6), 649-652, 2007

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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