Behavior of Cell-Mediated Immune Functions and Humoral Factors in Cancer Patients

  • YAMAUCHI Susumu
    Division of Clinical Microbiology, School of Medicine Tokai University
  • OZAWA Atsushi
    Department of Microbiology, School of Medicine Tokai University
  • TAJIMA Tomoo
    Department of 2nd Surgery, School of Medicine Tokai University
  • MITOMI Toshio
    Department of 2nd Surgery, School of Medicine Tokai University

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説明

Sequential observations on in vitro lymphocyte transformation in responses to PHA and serum protein levels in cancer patients were assessed. Lymphocyte responses to PHA in cancer patients were significantly lower than those in normal healthy individuals. These findings indicate that cellular immunity as judged by the in vitro proliferative capacity of lymphocytes in response to PHA is impaired in cancer patients. The average levels of serum proteins in cancer patients were not significantly affected by malignant tumor bearing conditions. The IgG, Hp and Cp levels in sera derived from cancer patients were slightly higher than those of control groups and were elevated after surgery. Quantitave abnormalities with increases or decreases in the IgA levels were observed especially in patients with neoplastic lesions of epithelial glandular tissues. These findings suggest that abnormalities in IgA level reflect a specific manifestation of a neoplastic lesion in the epithelial glandular tissue. In addition, correlations between immunological responses and malnourishment conditions in cancer patients are discussed.

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詳細情報 詳細情報について

  • CRID
    1571980076879239424
  • NII論文ID
    110004690438
  • NII書誌ID
    AA00863975
  • ISSN
    03850005
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

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