BASIC STUDIES OF CITRATE THERAPY ON UROLITHIASIS : The Effect of Citrate on Solubility of Calcium Oxalate Crystal and on Calcium Deposition of Murine Kidney in Experimental Oxalate Stone

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  • 尿路結石症におけるクエン酸療法の基礎的検討 : クエン酸の蓚酸カルシウム結晶溶解作用およびラット実験結石に与える影響

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Some basal examinaitons about the effect of citrate on calcium oxalate were carried out. These studies consisted of following three experiments, the effect on the solubility of calcium oxalate, the inhibitory activity to the ability of calcium oxalate crystal forming and inhibitory effect of citrate on renal tubular deposits of calcium oxalate crystal in the rat. The following results have been obtained: 1) Citrate increased solubility of calcium oxalate within a range of physiological pH and the effect was enhanced in an alkaline condition. Cirtrate also increased solubility of hydroxyapatite in comparison with control, whereas an extreme decrease was confirmed in the alkaline condition. 2) The ability of crystal forming of calcium oxalate was studied using the aggregometer. As concentration of citrate increased, crystal forming of calcium oxalate decreased. 3) Calcium oxalate crystals were developed in the renal tubules of rats that received ethylene glycol (0.4%). Forming of these crystals was markedly suppressed by administration of citrate concomitantly. These results suggested the possibility that citrate might inhibit the formation of calcium oxalate stone and might be useful for actual clinical treatment of calcium oxalate stone.

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