Bioactive Saponins and Glycosides.VI.Elatosides A and B, Potent Inhibitors of Ethanol Absorption, from the Bark of Aralia elata SEEM. (Araliaceae) : The Structure-Requirement in Oleanolic Acid Glucuronide-Saponins for the Inhibitory Activity

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Description

Potent inhibitors of ethanol absorption, elatosides A and B, were isolated from the bark of Aralia elata SEEM. through bioassay-guided separation together with elatosides C and D and four known oleanolic acid glucuronide-saponins, spinasaponin A, spinasaponin A 28-O-glucoside, and stipuleanosides R_1 and R_2. The structures of elatosides A, B, C, and D were determined on the basis of chemical and physicochemical evidence as oleanolic acid 3-O-{[β-D-xylopyranosyl (1→2)][β-D-galactopyranosyl (1→3)]}-β-D-glucopyranosiduronic acid, oleanolic acid 3-O-{[β-D-galactopyranosyl (1→2)] [β-D-galactopyranosyl (1→3)]}-β-D-glucopyranosiduronic acid, and their 28-O-glucopyranosyl esters, respectively.The inhibitory effect of various oleanolic acid 3,28-O-bisdesmosides, oleanolic acid 3-O-monodesmosides, and oleanolic acid on ethanol absorption was examined and it was found that the 3-O-glucuronide moiety and the 28-carboxyl group in oleanolic acid glucuronide-saponin were required to exert the inhibitory activity.

Journal

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 44 (10), 1915-1922, 1996-10-15

    The Pharmaceutical Society of Japan

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Keywords

Details 詳細情報について

  • CRID
    1571980077279347584
  • NII Article ID
    110003631785
  • NII Book ID
    AA00602100
  • ISSN
    00092363
  • Text Lang
    en
  • Data Source
    • CiNii Articles

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