Chemistry of Lipid of the Posthemolytic Residue or Stroma of Erythrocytes:XVI. Occurrence of Ceramide Pentasaccharide in the Membrane of Erythrocytes and Reticulocytes of Rabbit

J-STAGE
  • ETO TOMOKO
    Department of Biochemistry, Faculty of Medicine, University of Tokyo
  • ICHIKAWA YOICHI
    Department of Biochemistry, Faculty of Medicine, University of Tokyo
  • NISHIMURA KENJI
    Department of Biochemistry, Faculty of Medicine, University of Tokyo
  • ANDO SUSUMU
    Department of Biochemistry, Faculty of Medicine, University of Tokyo
  • YAMAKAWA TAMIO
    Department of Biochemistry, Faculty of Medicine, University of Tokyo

抄録

Glycolipids were obtained from rabbit erythrocytes and reticulocytes. A new glycolipid, galactosyl-(1→3)-galactosyl-(1→_3)-N-acetylglucosaminyl-(1→3)-galactosyl-(1→4)-glucosyl ceramide, was found as the main component of erythrocyte glycolipids. Galactosyl-(1→4)-galactosyl-(1→4)-glucosyl ceramide and a small amount of dihexosyl ceramide were also found.<br> Unlike mature erythrocyte glycolipids, those of reticulocytes contain much mono- and di-hexosyl ceramide and an unknown glycolipid in addition to trihexosyl ceramide and ceramide pentasaccharide, suggesting that these glycolipids are metabolized actively in immature cells.<br> The structure of the carbohydrate moiety in the ceramide pentasaccharide is very similar to that of the blood group B active mucoid from body fluids and the glycolipid inhibited hemagglutination of human B-erythrocytes by the corresponding iso-antibody.

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