STUDIES ON THE METHYLATION OF PYRIDINE-COMPOUND IN ANIMAL-ORGANISMS:V. COMPARISON WITH THE BEHAVIOUR OF NICOTINIC ACID IN SOME VERTEBRATE ANIMALS

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1. An attempt has been made to compare the behaviours of nicotinic acid in rabbit, domestic fowl, tortoise and frog by the chromatographic techniques.<br> 2. The rabbit, fowl, tortoise, and frog converts nicotinic acid into nicotinamide, which is partly methylated into N1-methylnicotinamide in rabbit, tortoise, and frog except fowl showing quantitative difference and other part of it is oxidized to N1-methyl-6-pyridone-3-carboxamide in rabbit.<br> 3. In fowl, nicotinic acid seems to be conjugated with ornithine into nicotinoyl-ornithine-like substance, while in rabbit, tortoise and frog it is conjugated with glycine.<br> The author wishes to express his cordial thanks to Dr. M. Tomita for his con-tinuous advice and encouragement.

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