A True Splennic Cyst : An Immunohistologic Study of Lining Cell of the Cyst

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  • Akira Ihara
    First Department of Surgery, ST. Marianna University School of Medicine
  • Rintarou Hashizume
    First Department of Surgery, ST. Marianna University School of Medicine
  • Kenji Katayama
    First Department of Surgery, ST. Marianna University School of Medicine
  • Hiroyuki Komoriyama
    Department of Surgery, Tokyo Hospital of ST. Marianna University School of Medicine
  • Hiroyoshi Yokose
    Department of Surgery, Tokyo Hospital of ST. Marianna University School of Medicine
  • Takuhiko Ehira
    Department of Surgery, Tokyo Hospital of ST. Marianna University School of Medicine
  • Suguru Yamaguchi
    Department of Surgery, Tokyo Hospital of ST. Marianna University School of Medicine
  • Toshihito Shinagawa
    Department of Pathology, Tokyo Hospital of ST. Marianna University School of Medicine

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Other Title
  • 真性脾嚢胞の1例.嚢胞被覆細胞の免疫組織学的検討

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A 26-year-old woman complained of a tumor in the left hypochondrial region. The diagnosis of a splenic cyst was preoperatively made by CT, angiography and splenic scintigraphy. The spleen with its cyst was resected en bloc. The specimen weighed 1,800g and measured 20x18x12 cm. Histopathological examination revealed a true cyst, lined by a single layer of flattened cells In order to determine the origin of the true splenic cyst we performed an immunohistochemical examination. Both keratin and vumentin as mesothelial markers and cancer antigen(CA 125) also showed positive staining. However neither espithelial mambrane antigen(EMA) as an epithelial marker, nor factor-VIII-related antigen as an endothelial marker, was stained. From the above results this true sprenic cyst is considered to be of mesothelial origin.

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