CHEMICAL MODIFICATION OF APHIDICOLIN AND THE INHIBITORY EFFECTS OF ITS DERIVATIVES ON DNA POLYMERASE α IN VITRO(Communications to the Editor)

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説明

Various derivatives of aphidicolin (1) were prepared and their inhibitory effects on purified DNA polyrmerase α in vitro were assayed. Among these derivatives, the new 3α-, 17, 18-trihydroxyaphidicol-15-ene (24) was as inhibitory as the known 3-deoxy- and 3-oxoaphidicolins, (20) and (14). All the other derivatives with modification of any of the hydroxyl groups of 1 had no effect on the enzyme in vitro. The structure-activity relationships are discussed concerning functionalization on the aphidicolane ring.

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詳細情報 詳細情報について

  • CRID
    1572543027186203136
  • NII論文ID
    110006281104
  • NII書誌ID
    AA00602100
  • ISSN
    00092363
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

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