軽症本態性高血圧症に対するカリウムの降圧作用に関する研究

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  • Effect of potassium loading in mild eht

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In order to confirm and investigate the hypotensive effect of a high potassium intake, we compared BP, UV, urinary electrolyte, serum electrolyte, plasma renin activity and plasma aldosterone concentration in 10 inpatients under usual diet (U group, NaCl 10g / day) versus 10 inpatients under low sodium diet (L group, NaCl 3g / day) or in 24 outpatients during no drugs (N group) versus 16 outpatients with thiazide therapy (T group) with mild essential hypertension. After potassium administration, BP was significantly reduced in each groups. Changes of U-Na was negative correlated with changes of MBP at inpatients (r=-0.70, p<0.001). U-Na was significantly increased at 2, 3, 4 day in U group but in L group U-Na was no changed. Furthermore, the MBP reduction in U group was significantly greater than L group (p<0.02) and the MBP reduction in N group was significantly greater than in T group (p<0.05). These results suggest that the hypotensive effect of high potassium intake may be caused by natriuresis. But in L group and T group blood pressure was significantly decreased without natriuresis and body weight loss. At inpatients changes of S-K was significantly correlated with changes of MBP (r=-0.56, p<0.01) and at L group changes of S-K was closely significantly correlated with changes of MBP (r=-0.72, p<0.02). At N group changes of S-K was significantly correlated with· changes of MBP (r=-0.49, p<0.02). At T group significant correlations were not found between S-K and MBP. These results suggest that the hypotensive effect of a high potassium diet may be caused by the other factors of natriuresis.

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