A Histological Analysis of T and B Cells in Periodontal Tissue Destruction

  • Matsuo Takashi
    Department of Conservative Dentistry, Tokushima University School of Dentistry
  • Tagawa Chisato
    Department of Conservative Dentistry, Tokushima University School of Dentistry
  • Ozaki Kazumi
    Department of Conservative Dentistry, Tokushima University School of Dentistry
  • Noiri Yuichiro
    Department of Conservative Dentistry, Tokushima University School of Dentistry
  • Ebisu Shigeyuki
    Department of Conservative Dentistry, Tokushima University School of Dentistry

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説明

We immunohistologically examined the cell densities and distribution of T and B cells in periodontitis and analyzed their relationship in terms of periodontal tissue destruction. Specimens were labeled with monoclonal antibodies for T cells (CD3) and B cells (CD20) and developed using the double staining technique. CD3^+ cells appeared in low density infiltrates and increased gradually with the number of total infiltrates; in contrast, CD20^+ cells did not appear in small infiltrates but increased rapidly with the number of infiltrates. The number of fibroblastic cells negatively correlated with that of the total infiltrates and CD20^+ cells, but it did not correlate with the number of CD3^+ cells. These findings suggest that the T cells infiltrated into the inflamed sites at the onset and increased gradually with the development of inflammation and that B cells infiltrated later than T cells and their number increased rapidly with inflammation.

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  • Oral medicine & pathology

    Oral medicine & pathology 1 (2), 77-83, 1996-07

    特定非営利活動法人日本臨床口腔病理学会

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