Bioactive Saponins and Glycosides. II. Senegae Radix (2): Chemical St4ructures, Hypoglycemic Activity, and Ethanol Absorption-Inhibitory Effect of E-Senegasaponin c, Z-Senegasaponin c, and Z-Senegins II, III, IV

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Abstract

Following the characterization of E-senegasaponins a and b and Z-senegasaponins a and b, new bioactive saponins named E-senegasapinin c and Z-senegasapinin c were isolated from Senegae Radix, the root of Polygala senega L. var. latifolia TORREY et GRAY., together with Z-senegins II, III, and IV. The chemical structures of E and Z-senegasaponins c and Z-senegins II, III, and IV were elucidated on the basis of chemical and physicochemical evidence, and the geometrical isomerc structures of the 4''-methoxycinnamoyl and 3'', 4''-dimethoxycinnamoyl groups in these saponins were found to show tautomer-like behavior under irradiation with fluorescent lamps.E and Z-Senegasaponins c and E and Z-senegins II, III, and IV were found to exhibit hypoglycemic activity in the oral D-glucose tolerance test. (E) and (Z)-Senegins II also showed an inhibitory effect on alcohol absorption in rats.

Journal

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 44 (7), 1305-1313, 1996-07-15

    The Pharmaceutical Society of Japan

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Keywords

Details 詳細情報について

  • CRID
    1572824502208655360
  • NII Article ID
    110003632076
  • NII Book ID
    AA00602100
  • ISSN
    00092363
  • Text Lang
    en
  • Data Source
    • CiNii Articles

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