Growth-inhibitory effect of hexa-N-acetylchitohexaose and chitohexaose against Meth-A solid tumor

被引用文献20件

書誌事項

公開日
1988
公開者
公益社団法人日本薬学会

この論文をさがす

説明

Two oligosaccharides, hexa-N-acetylchitohexaose (NACOS-6) and chitohexaose (COS-6), consisting solely of N-acetyl-D-glucosamine and D-glucosamine, respectively, were found to be growth-inhibitory against Meth-A solid tumor transplanted into BALB/c mice, when each oligosaccharide was administered i.v. at a dose of more than 1 mg/kg. Mouse peritoneal macrophages elicited with casein underwent activation with these oligosaccharides in vitro to produce interleukin 1. Spleen cells from mice given these oligosaccharides also underwent acceleration of interleukin 2 production and cytolytic T-lymphocyte differentiation. Thus, the antitumor mechanism of NACOS-6 and COS-6 was assumed to involve increased production of lymphokines including interleukins 1 and 2,sequentially, leading to the manifesation of antitumor effect through proliferation of cytolytic T-lymphocytes.

収録刊行物

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 36 784-790, 1988

    公益社団法人日本薬学会

被引用文献 (20)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ