“ALLITHIAMINE” A NEWLY FOUND DERIVATIVE OF VITAMIN B<sub>1</sub>

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We have found the fact that when we let an extract of plants of allium species, e. g. garlic, react with thiamine, thiamine turns to a hitherto unknown compound which was negative to thiochrome reaction in vitro, but acted as thiamine in vivo. We have succeeded in isolating this compound and designated it as allithiamine.<br> Allithiamine has the structure of thiamine allyl disulfide and forms as the resultant compound when allicin reacts with thiamine.<br> Allithiamine simulates thiamine-disulfide in its biochemical properties, but behaves in a different way from generally accepted behaviors of thiamine or its homologues in that it is highly soluble in organic solvent.<br> Necessary conditions for quantitative determination of allithiamine have been discussed.<br> The authors wish to thank Dr. U. Miura, Kyoto University for encouragement druing the course of this investigation. The experiments were aided by a grant from the Ministry of Education.

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