Biochemistry of Organ Glycolipids:II. Isolation of Human Kidney Glycolipids

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  • MAKITA AKIRA
    the Department of Chemistry, the Institute for Infectious Diseases, the University of Tokyo

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説明

From human kidney, following glyco-lipids were isolated in pure state and char-acterized:<br> 1. Cerebroside (CMH); the material contained more galactose than glucose and larger amounts of hydroxy acids (71% of the total acids), in contrast to spleen CMH in which glucose and normal fatty acids were predominant.<br> 2. Cerebroside sulfuric ester (CSE); the material contained only galactose and larger amounts of hydroxy acids (89% of the total acids).<br> 3. Ceramide dihexoside (CDH).<br> 4. Ceramide trihexoside (CTH).<br> In CDH and CTH, constituent hexoses were galactose and glucose.<br> 5. Hexosamine-containing mucolipid (kidney ML-I); the composition and the pro-perties of the material were similar to those of the human red cell globoside.<br> The author wishes to thank deeply Prof. T. Yama-kawa for his guidance, encouragement and helpful discussion.<br> Thanks are also due to Associate Prof. T. Tsumita for helpful discussion.<br> In addition, the author wishes to express his gratitude to Drs. S. Yoshimura, J. Koshinaga and M. Okudaira of Tokyo-to Medical Examiner's Office for the supply of human kidney material. Thanks are also due to Miss M. Iwanaga for the preparation of glycolipid materials, to Miss N. Kawamura and Mrs. Y. Takemura for the elemental analysis, and to Miss C. Hashimoto for the gas chromatographic an-lysis of the fatty acids.

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