High-dose intravenous intact IgG infusion in refractory autoimmune hemolytic anemia (Evans syndrome)

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AUTOIMMUNE HEMOLYTIC ANEMIA in childhood has been reported to have two main clinical patterns: acute and chronic. The acute type responds well to corticosteroid therapy and transfusion, but the chronic type requires prolonged corticosteroid therapy, immunosuppressive agents, splenectomy, and plasma exchangeJ -3 Evans syndrome, a combination of AIHA and idiopathic thrombocytopenic purpura, in particular is usually refractory and relapses exclusively in chronic-type AIHA. 4 Recently, high-dose intravenous lgG therapy for the treatment of ITP has been reported, 5-7 but it has not been successful in the management of AIHA. We attempted this therapy in a boy with refractorY Evans syndrome because of the presumed common pathophysiologic characteristics of immune hemolysis and immune thrombocytopenia, and successful control was obtained.

Journal

  • J. Pediatr.

    J. Pediatr. 107 744-746, 1985

    Elsevier BV

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