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A Simple Labeled Test Meal for the Evaluation of Gastric Emptying

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  • Ishii Keita
    Department of Internal Medicine, Kitasato University School of Medicine
  • Tanabe Satoshi
    Department of Internal Medicine, Kitasato University School of Medicine
  • Mitsuhashi Toshiharu
    Department of Internal Medicine, Kitasato University School of Medicine
  • Saigenji Katsunori
    Department of Internal Medicine, Kitasato University School of Medicine

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  • アイソトープを用いた胃排出能検査における簡易試験食の試み

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Abstract

We developed a simple test meal for the evaluation of gastric emptying. Preparation of a test meal for routine clinical use in institutions should be as simple as possible. The newly developed test meal consists of instant noodles labeled with 37 MBq (1 mCi) technetium-99m and dose not require the use of cooking utensils. The test meal was given with drinking water (180ml) to healthy adult volunteers (6 men, 34.5±2.2 years old) and gastric emptying was measured at 0, 5, 10, 15, 30, 45, 60, 80, 100, 120 minutes after the end of the meal, and results were compared with those derived without drinking water. The emptying pattern of the test meal with water exhibited an exponential pattern typical of a liquid meal, and that without water formed a linear pattern after an initial lag phase in keeping with gastric emptying of a solid meal. In addition, the test meal was given to 11 patients of diabetic gastroparesis (5 men, 6 women, 50.4±4.5 years old), and gastric emptying was measured. At each period evaluated, emptying was significantly slower in diabetic gastroparesis than in healthy controls (6 men, 1 woman, 32.1±3.0 years old). These results show that the test meal is realiable and applicable to the clinical assessment of gastric emptying, while fulfilling the need for simplicity.

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