Synthesis and Biological Activities of 2,3-Dimethyl-1,4-benzoquinones Having Alkylthio and Arylthio Side Chains(Medicinal Chemistry,Chemical)

被引用文献1件
  • 森 浩一
    Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
  • 高橋 京子
    Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
  • 紀氏 健雄
    Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
  • 佐用 博照
    Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

この論文をさがす

説明

New 2,3-dimethyl-1,4-benzoquinones having an alkylthio or arylthio side chain at the 5-position and two alkylthio side chains at the 5- and 6-position were synthesized as possible antimetabolites of coenzyme Q. These compounds were tested for inhibition of coenzyrne Q in mitochondrial succinoxidase and reduced nicotinamide adenine dinucleotide (NADH)-pxidase systems, and were found to show greater inhibition of the NADH-oxidase system than of the succinoxidase system. 5,6-Di-octylthio-2,3-dimethyl-1,4-benzoquinone showed greater inhibitory activities than 5-alkylthio-2,3-dimethyl-1,4-benzoquinones. 5-Arylthio-2,3-dimethyl-1,4-benzoquinones showed potent inhibitory activities towards both enzyme systems.

収録刊行物

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 35 1270-1274, 1987

    公益社団法人日本薬学会

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

  • CRID
    1573105977138944256
  • NII論文ID
    110006281045
  • NII書誌ID
    AA00602100
  • ISSN
    00092363
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

問題の指摘

ページトップへ