Studies on Anti-inflammatory Agents. XV. : Toxicological Studies of 2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno [2,3-c] pyridine Hydrochloride (2)
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- NANBA TAKEFUMI
- Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.
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- HAMADA YUJI
- Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.
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- IZAKI KATSUHIRO
- Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.
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- IMAMURA HIROSHI
- Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.
Bibliographic Information
- Other Title
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- 抗炎症薬に関する研究(第15報) : 2-Amino-3-ethoyxcarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Hydrochlorideの毒性 その2
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Description
2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno-[2,3-c] pyridine hydrochloride (Y-3642-HCl) was given orally to ICR-JCL mice in a dose of 1000 or 100 mg/kg/day from 7th to 12th day of pregnancy. The compound lowered the survival rate of offsprings, but did not show any influence on the development of fetuses. Y-3642-HCl displayed no marked teratogenic influence on fetuses of the mouse. Y-3642-HCl was given orally to Wistar-King rats in a dose of 700 or 70 mg/kg/day from 9th to 14th day of pregnancy. The compound, in a dose of 700 mg/kg decreased the growth rate of pregnant rats and fetuses, and delayed the development of fetuses. There was no evidence that Y-3642-HCl had any teratogenic influence on fetuses of the rat.
Journal
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- Journal of the Pharmaceutical Society of Japan
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Journal of the Pharmaceutical Society of Japan 90 (11), 1447-1451, 1970-11-25
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1573105977295585024
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- NII Article ID
- 110003654304
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- NII Book ID
- AN00284903
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- ISSN
- 00316903
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- Text Lang
- ja
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- Data Source
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- CiNii Articles