Atrial Natriuretic Peptide (ANP) -Granules of Auricular Cardiocytes in Aging Mongolian Gerbils
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- MIFUNE Hiroharu
- <I>Institute of Animal Experiment, Kurume University School of Medicine</I>
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- SUZUKI Syusaku
- <I>Institute of Laboratory Animal Science, Kagoshima University, Faculty of Medicine</I>
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- NODA Yasutaka
- <I>Institute of Animal Experiment, Kurume University School of Medicine</I>
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- HAYASHI Yoshihiro
- <I>Laboratory of Veterinary Anatomy Faculty of Agriculture, The University of Tokyo</I>
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- MOCHIZUKI Koshi
- <I>Laboratory of Biomedical Science, College of Agriculture and Veterinary Medicine, Nihon University</I>
Bibliographic Information
- Other Title
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- スナネズミの心耳筋細胞における心房性ナトリウム利尿ペプチド (ANP) 顆粒の加齢に伴う変化
Abstract
The atrial natriuretic peptide (ANP) -granules of right auricular cardiocytes were studied in aging Mongolian gerbils by immunohistochemistry and transmission electron microscopy, and analyzed by ultrastructural morphometry. Immunohistochemically, the ANP immunoreactions were weaker in 3 and 4-year-old animals than in 90-day-old, 1-and 2-year-old animals. There was no difference in the reaction among 90-day-old, I and 2-year-old animals, or between 3 and 4-year-old animals. Ultrastructurally, the morphological features in 1 and 2-year-old animals were similar to those of 90-day-old animals, but distinct in 3 and 4-year old animals by the presence of a few lysosomal structures in the cell. By ultrastructual morphometry, number and diameter of ANP-granules of 3 and 4-year-old animals were significantly smaller than those in the 90-day-old, 1 and 2-year-old. There was no significant difference in number and diameter among the 90-day-old, 1 and 2-year-old, or between the 3 and 4-year-old.
Journal
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- Experimental Animals
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Experimental Animals 40 (4), 573-577, 1991
Japanese Association for Laboratory Animal Science
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Details 詳細情報について
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- CRID
- 1573105977810396928
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- NII Article ID
- 130006940101
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- Data Source
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- CiNii Articles