Photosensitizer-Induced Lipid Peroxidation in Retinal Homogenates under Illumination

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In this study, the effect of photosensitizers on lipid peroxidation in the retina was investigated. Porcine retinal homogenate was exposed to illumination from a fluorescent lamp with or without photosensitizers such as hematoporphyrin, rose bengal, and fluorescein for 60min. The control, which was exposed to illumination without photosensitizers, did not show a significant increase in lipid peroxidation. However, lipid peroxidation in the homogenates exposed to illumination with photosensitizers increased significantly and in a dose-dependent manner. For concentrations of more than 100μM of all three photosensitizers, lipid peroxidation in the retina homogenates increased to a level approximately 2-3 times higher than that in the sample before illumination, and to a level 10 times higher than that of the control. α-Tocopherol inhibited hematoporphyrin-induced lipid peroxidation in a dose-dependent manner, but superoxide dismutase did not show an inhibitory effect.

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詳細情報 詳細情報について

  • CRID
    1573387452489735808
  • NII論文ID
    120005305407
  • ISSN
    09120009
  • Web Site
    http://hdl.handle.net/10271/2424
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

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