Effects of Germfree Status and Food Restriction on Longevity and Growth of Mice

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  • TAZUME Seiki
    <I>Department of Microbiology, Occupational Health, School of Medicine, Tokai University, Tokai University</I>
  • UMEHARA Keiko
    <I>Department of Microbiology, Occupational Health, School of Medicine, Tokai University, Tokai University</I>
  • MATSUZAWA Hideyuki
    <I>Department of Microbiology, Occupational Health, School of Medicine, Tokai University, Tokai University</I>
  • AIKAWA Hiroyuki
    <I>Department of Environmental Medicine and Occupational Health, School of Medicine, Tokai University</I>
  • HASHIMOTO Kazuo
    <I>Department of Microbiology, Occupational Health, School of Medicine, Tokai University, Tokai University</I>
  • SASAKI Shogo
    <I>Department of Microbiology, Occupational Health, School of Medicine, Tokai University, Tokai University</I>

Bibliographic Information

Other Title
  • マウスの寿命および成長に及ぼす無菌状態と制限食の影響

Description

An investigation was undertaken to study the effects of germfree (GF) status and mild food restriction on life span in GF and specific pathogen-free (SPF) male ICR mice either full-fed (ad libitum) or on a restricted diet of 4.5 grams per day (equivalent to approximately 80% of full-fed intake) from five-week-old. The mean life span of the full-fed SPF and GF mice was 75.9 and 88.9 weeks respectively, whie the mean life span of the food-restricted SPF and GF mice was 117.5 and 109.6 weeks, respectively. Mice in both GF and SPF food-restricted groups were characterized by lower body weight and increased survival. These findings suggest that the cessation of growth may be importantly and perhaps causally related to longevity. The GF mice survived longer than the SPF mice, but the combination of GF status with food restriction did not seem to extend life span more than food restriction alone.

Journal

  • Experimental Animals

    Experimental Animals 40 (4), 517-522, 1991

    Japanese Association for Laboratory Animal Science

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