Biosynthesis of liver catalase in rats treated with allylisopropylacetylcarbamide. II. Double-labeling of catalase with (14C)leucine and .DELTA.-(3H)aminolevulinic acid.:II. Double-labeling of Catalase with [14C] Leucine and δ-[3H] Aminolevulinic Acid

KAWAMATA Fumiko, SAKURAI Toshiharu, HIGASHI Tokuhiko

Biosynthesis of liver catalase in rats treated with allylisopropylacetylcarbamide. II. Double-labeling of catalase with (14C)leucine and .DELTA.-(3H)aminolevulinic acid.:II. Double-labeling of Catalase with [14C] Leucine and δ-[3H] Aminolevulinic Acid

J-STAGE

KAWAMATA Fumiko

Department of Biochemistry, School of Pharmaceutical Sciences, Showa University
SAKURAI Toshiharu

Department of Biochemistry, School of Pharmaceutical Sciences, Showa University
HIGASHI Tokuhiko

Department of Biochemistry, School of Pharmaceutical Sciences, Showa University

この論文をさがす

CiNii Books

説明

Double-labeling of liver catalase [EC 1. 11. 1. 6] with [¹⁴C] leucine and δ-[³H] arninolevulinic acid was carried out both in vivo and in vitro using rats treated with allylisopropylacetylcarbamide (Sedormid). These radioactive precursors were incorporated into catalase at a lower rate than in normal rats. In particular, the incorporation of ³H was remarkably inhibited. The results suggest that the administration of Sedormid can inhibit synthesis of the protein moiety of catalase, and possibly interfere with the binding of heme to the catalase protein.