SYNTHESIS OF 5-FLUOROARACHIDONIC ACID AND ITS BIOTRANSFORMATION TO 5-FLUORO-12-HYDROXYEICOSATETRAENOIC ACID(Communications to the Editor)

田口 武夫, 瀧川 智之, 五十嵐 東, 小林 義郎, 田中 洋子, Jubiz William, Briggs Robert G.

SYNTHESIS OF 5-FLUOROARACHIDONIC ACID AND ITS BIOTRANSFORMATION TO 5-FLUORO-12-HYDROXYEICOSATETRAENOIC ACID(Communications to the Editor)

被引用文献1件

田口武夫

Tokyo College of Pharmacy
瀧川智之

Tokyo College of Pharmacy
五十嵐東

Tokyo College of Pharmacy
小林義郎

Tokyo College of Pharmacy
田中洋子

Veterans Administration Medical Center and Department of Medicine, Albany Medical College
Jubiz William

Veterans Administration Medical Center and Department of Medicine, Albany Medical College
Briggs Robert G.

Wadsworth Center for Laboratories and Research, New York State Department of Health

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説明

The synthesis of 5-fluoroarachidonic acid (1) was achieved from the intermediate (E)-5, 6-dihydroxy-2-fluorohex-2-enoate 5, 6-acetonide (5). Incubation of 1 with human platelets yielded 5-fluoro-12-hydroxyeicosatetraenoic acid (5F-12-HETE, 2).