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SYNTHESIS OF 5-FLUOROARACHIDONIC ACID AND ITS BIOTRANSFORMATION TO 5-FLUORO-12-HYDROXYEICOSATETRAENOIC ACID(Communications to the Editor)
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- TAGUCHI T.
- Tokyo College of Pharmacy
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- Takigawa Tomoyuki
- Tokyo College of Pharmacy
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- Igarashi Azuma
- Tokyo College of Pharmacy
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- Kobayashi Yoshiro
- Tokyo College of Pharmacy
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- Tanaka Yoko
- Veterans Administration Medical Center and Department of Medicine, Albany Medical College
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- Jubiz William
- Veterans Administration Medical Center and Department of Medicine, Albany Medical College
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- Briggs Robert G.
- Wadsworth Center for Laboratories and Research, New York State Department of Health
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Description
The synthesis of 5-fluoroarachidonic acid (1) was achieved from the intermediate (E)-5, 6-dihydroxy-2-fluorohex-2-enoate 5, 6-acetonide (5). Incubation of 1 with human platelets yielded 5-fluoro-12-hydroxyeicosatetraenoic acid (5F-12-HETE, 2).
Journal
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- Chem. Pharm. Bull.
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Chem. Pharm. Bull. 35 1666-1669, 1987
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1573668927093058176
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- NII Article ID
- 110006281111
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- NII Book ID
- AA00602100
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- ISSN
- 00092363
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- Text Lang
- en
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- Data Source
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- CiNii Articles
