Experimental and clinical studies on mr imaging of malignant melanoma : MR imaging and pathologic correlation on hamster malignant melanoma and clinical application

  • Aoki Osamu
    Department of Radiology, Kobe University School of Medicine

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  • 悪性黒色腫のMRI診断に関する実験的並びに臨床的研究 : ハムスター黒色腫におけるMR像と病理像との対比と臨床例への応用

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To increase the diagnostic accuracy of magnetic resonance imaging (MRI) on human malignant melanoma, MR images of hamster malignant melanoma which resembled human malignant melanoma biologically and pathologically were obtained and compared with the pathological findings of the tumor. The viable part of the tumor was demonstrated as slightly hyperintense area on the T_1-weighted (T_1 W) images and hyperintense area on the T_2 W images. The coagulation necrosis was hyperintense on the Tl W images and slightly hyperintense on the T_2 W images. The liquefaction necrosis was quite hypointense on the T_1 W images and quite hyperintense on the T_2 W images. Consequently MRI could distinguish the viable tumor from the necrotic part of hamster melanoma on the T_1 and T_2 W images. Based on this experimental study, MRI on 24 lesions of human malignant melanoma was performed. In 21 out of 24 lesions, the viable part of melanoma was demonstrated as slightly hyperintense on the T_1 W images and hyperintense on the T_2 W images. Only 3 lesions revealed hyperintense on the T_1 W images and hypointense on the T_2 W images due to the paramagnetic effect of melanin. It was considered that the signal intensity of melanoma was more affected by the necrotic change of tumor than the paramagnetic effect of melanin.

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