A CONTRIBUTION TO THE METABOLISM OF TRYPTOPHANE

  • KURODA YOSHIO
    Department of Medical Chemistry, Kyushu National University

Description

Our observations on the metabolism of D-tryptophane and indolepyruvic acid are in general agreement with those of other investigators.<br> After the subcutaneous administration of indolepyruvic acid to rabbits, the output of kynurenine was not to ascertain, not only by isolation of crystalline substance, but also by paper chromatography, although the kynurenine yellow-like substance was obtained.<br> It is very probable that indolepyruvic acid will be converted directly to kynurenic acid, not through kynurenine anyhow. Ellin-ger-Matsuok a's way is, therefore, applicable as the secondary way to form kynurenic acid from tryptophane.<br> (We are greatly indebted to Prof. S. U tzino in Kyoto National University for his kind contribution of a large quantity of indole. We also appreciate the Department of Education for the grant of “Research Fund of Science” for this work. R yozo Hirohata).

Journal

Details 詳細情報について

  • CRID
    1573950402731746688
  • NII Article ID
    130006871427
  • Text Lang
    en
  • Data Source
    • CiNii Articles

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