PYRUVATE AND α-KETOGLUTARATE IN BLOOD AND URINE

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  • SHIMIZU TAIJI
    Department of Biochemistry, Niigata University School of Medicine

説明

1. The normal value of pyruvic acid in the human blood was 0.85±0.02 mg./dl., and that of α-ketoglutaric acid was 0.60±0.02 mg./dI. The normal excretion of pyruvic acid in daily human urine was 21-t 1.7mg. and the concentration of the acid of daily urine was 0.91±0.11 mg./dl. The normal excretion of α-ketoglutaric acid in daily urine was 30±3.6 mg. and the concentration of the acid of daily urine was 1.10±10.12 mg./dl.<br> 2. After exercise both blood pyruvate and α-ketoglutarate was increased, and the latter returned to the normal value faster than the former.<br> 3. One hour after the injection of 3mg. of thiamine both pyruvate and α-ketoglutarate in blood were decreased. One hour after the injection of 10 mg. of riboflavin pyruvate in blood increased slightly and α-ketoglutarate decreased. One hour after the injection of both vitamins together, pyruvate did not show any remarkable change, whereas a-ketoglutarate was decreased.<br> 4. The thiamine injection repressed the increase of both acids after exercise, and the riboflavin injection repressed the increase of α-ketoglutaric acid stronger than that of pyruvic acid. When both vitamins were injected together, the repression was the strongest.<br> The author wishes to express his sincere'thanks to Prof. N. Shimazono for his guidance and helpful advice.

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