A randomized, double‐blind, placebo‐controlled study of cd4 monoclonal antibody therapy in early rheumatoid arthritis

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  • A randomized, double-blind, placebo-controlled study of CD4 monoclonal antibody therapy in early rheumatoid arthritis

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<jats:title>Abstract</jats:title><jats:p><jats:italic>Objective</jats:italic>. To assess the efficacy of the CD4 monoclonal antibody (MAb) cM‐T412 in the treatment of early rheumatoid arthritis (RA).</jats:p><jats:p><jats:italic>Methods</jats:italic>. Sixty patients were enrolled in a 6‐week randomized, double‐blind, placebo‐controlled study investigating multiple dose regimens of cM‐T412. Thirty patients subsequently were enrolled in a 9‐month randomized, double‐blind, placebo‐controlled study investigating monthly single‐dose administrations of cM‐T412.</jats:p><jats:p><jats:italic>Results</jats:italic>. Analysis of clinical parameters revealed no changes in arthritis activity in the groups that received CD4 MAb or the placebo group, and no difference between the groups, in either in the first or the second part of the study. The number of circulating CD4+ cells decreased substantially in the patients treated with CD4 MAb.</jats:p><jats:p><jats:italic>Conclusion</jats:italic>. CD4 MAb treatment of patients with early RA induced no therapeutic effect.</jats:p>

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詳細情報 詳細情報について

  • CRID
    1574231876063259776
  • NII論文ID
    30025720348
  • DOI
    10.1002/art.1780380812
  • ISSN
    15290131
    00043591
  • PubMed
    7639806
  • データソース種別
    • CiNii Articles
    • OpenAIRE

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