THE EFFECT OF ISOSORBIDE DINITRATE ON EXERTIONAL HYPOTENSION IN OLD MYOCARDIAL INFARCTION
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- YAMABE HIROSHI
- Department of Internal Medicine, Devision I Kobe University, School of Medicine
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- KOBAYASHI KATSUYA
- Department of Internal Medicine, Devision I Kobe University, School of Medicine
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- INOUE TOMOO
- Department of Internal Medicine, Devision I Kobe University, School of Medicine
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- TAJIRI EIICHI
- Department of Internal Medicine, Devision I Kobe University, School of Medicine
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- FUJITANI KAZUHIRO
- Department of Internal Medicine, Devision I Kobe University, School of Medicine
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- FUKUZAKI HISASHI
- Department of Internal Medicine, Devision I Kobe University, School of Medicine
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Four patients with old myocardial infarction (OMI) revealed exertional hypotension in the treadmill exercise test. All had a multivessel disease, severe left ventricular dysfunction and exercise-induced ST depression or angina to indicate additional myocardial ischemia. After 5 mg of oral isosorbide dinitrate (ISDN), the response of blood pressure was improved with a delayed onset of ST depression or angina. To confirm the effect of ISDN on the pressure response to exercise, 26 patients with OMI were further studied. In patients without ST depression and angina (Group I), the systolic blood pressure (SBP) at the matched work load was significantly decreased after ISDN. However, in patients with ST depression or angina (Group II), SBP at the matched work load was not altered after ISDN. The increment of change in SBP due to ISDN, namely from the resting level to the matched work load, was significantly larger in Group II than in Group I. In addition, the patients with marked left ventricular dysfunction in Group I revealed a more change in SBP due to ISDN than the others in Group I. It was concluded that exertional hypotention or supressed pressure response of OMI could be corrected by 5 mg of oral ISDN due to its favorable effects on the exercise-induced myocardial ischemia and preexisting left ventricular dysfunction.
収録刊行物
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- Japanese circulation journal
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Japanese circulation journal 48 (3), 212-218, 1984-03-20
社団法人日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1574231876840176256
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- NII論文ID
- 110002578221
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- NII書誌ID
- AA00690731
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- ISSN
- 00471828
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles