Ga-Labeling of Immunoglobulin G with High Specific Radioactivity

古川 高子, 藤林 靖久, 福永 仁夫, 横山 陽

Ga-Labeling of Immunoglobulin G with High Specific Radioactivity

古川高子

Department of Health Chemistry, Kansai Medical University
藤林靖久

Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
福永仁夫

Division of Nuclear Medicine, Kawasaki Medical School
横山陽

Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University

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説明

To obtain radiogallium labeled immunoglobulin G with a high specific radioactivity for in vitro use, a ^<67>Ga source was purified by extraction from ^<67>Ga-gallium citrate with butyl acetate, and a ^<67>Ga-labeling solution was produced. This solution was then used to label a deferoxamine-immunoglobulin G conjugate. Both a very high specific radioactivity(872±56 MBq/mg) and a high labeling efficiency (94.0%) were achieved.