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Total Synthesis of Estrone via Estriol Dimethyl Ether
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- ASAKO TSUNEHIKO
- Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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- HIRAGA KENTARO
- Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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- MIKI TAKUICHI
- Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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Description
Meerwein-Ponndorf reduction of 3-methoxy-8,14-secoestra-1,3,5 (10), 9,15-pentaene-14,17-dione (III) yielded a mixture of rac-17α- and 17β-hydroxy-3-methoxy-8,14-secoestra-1,3,5 (10), 9,15-pentaen-14-one (XI and XII). Cyclization of 17β-benzoate of XII gave 3,16α-dimethoxy estra-1,3,5 (10), 8,14-pentaen-17β-ol 17-benzoate (XV), which was further transformed to rac-estrone (XXI).
Journal
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 21 (4), 697-702, 1973-04-25
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1574231877204551936
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- NII Article ID
- 110003621514
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- NII Book ID
- AA00602100
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- ISSN
- 00092363
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- Text Lang
- en
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- Data Source
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- CiNii Articles