Isotope Dilution Analysis for Urinary Fentanyl and its Main Metabolite, Norfentanyl, in Patients by Isotopic Fractionation using Capillary Gas Chromatography

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Other Title
  • キャピラリガスクロマトグラフィを用いた同位体希釈分析による患者尿中フェンタニルおよび主代謝物ノルフェンタニルの定量

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Description

Isotope dilution analysis was applied to determine urinary excretion of fentanyl (FT) and its main metabolite, norfentanyl (Nor-FT), by isotopic fractionation using a capillary gas chromatograph equipped with a surface ionization detector (SID). Urinary FT was determined quantitatively in the range of 0.4-40 ng/ml using deuterium labeled FT (FT-2H19) , as an internal standard. Nor-FT concentration was quantitatively determined in the range of 10-400 ng/ml using deuterium labeled Nor-FT (Nor-FT-^2H_<10>). No endogenous compounds or concomitant drugs interfered with the detection of FT and Nor-FT in the urine of patients. The present method will be useful for pharmacokinetic studies and the evaluation of drug interactions in FT metabolism.

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Details 詳細情報について

  • CRID
    1574231877275091328
  • NII Article ID
    110007408665
  • NII Book ID
    AN10064550
  • ISSN
    0288724X
  • Text Lang
    ja
  • Data Source
    • CiNii Articles

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